It appears that Mass Effect 3’s highly contentious endings won’t factor into the upcoming Mass Effect: Andromeda. This news comes from an interview Eurogamer conducted with Bioware head Aaryon Flynn at E3 last week.
"We acknowledged it in the endings of Mass Effect 3 and I think that's where we want to leave it for now,” said Aaryon. “We want this to be a new story and it would be very hard to say it's a new story but also that you need to understand how [the past trilogy] ended."
Mass Effect: Andromeda takes place in another galaxy, as mankind has expanded out to find itself a new home. The shift in location apparently allows for all possible endings to remain canon. "We've done it in such a way that allows all of those decisions you made to remain intact in the canon of the universe, but also allows a new story to begin."
There will be callbacks to the original trilogy, however. This will be in the form of certain alien races.
Mass Effect: Andromeda is slated for a 2017 release for PlayStation 4, Xbox One, and PC.